930628

VH 032 amide-alkyl C₃-acid

≥95%

• 同義詞: (4R), (S,R,S)-AHPC-CO-C₃-acid, L-Prolinamide, N-(4-carboxy-1-oxobutyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]
• 經驗公式（希爾表示法）: C₂₇H₃₆N₄O₆S
• CAS號碼: 2172819-73-5
• 分子量：: 544.66
• MDL號碼: MFCD32903592
• 分類程式碼代碼: 51471602
• NACRES: NA.21

屬性

• ligand: VH032
• 品質等級: 100
• 化驗: ≥95%
• 形狀: powder
• 官能基: carboxylic acid
• 儲存溫度: 2-8°C
• SMILES 字串: C([C@@H](NC(CCCC(O)=O)=O)C(C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
• InChI 密鑰: FKGREQKARAJLQH-JXALWOEJSA-N

描述

應用

VH 032 amide-alkyl C₃-acid is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal carboxyl group, allowing rapid conjugation of amine containing linkers. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

其他說明

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3