930547

Pomalidomide-PEG₁-C₂-azide

≥95.0%

• 同義詞: 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• 經驗公式（希爾表示法）: C₁₇H₁₈N₆O₅
• CAS號碼: 2271036-44-1
• 分子量：: 386.36
• MDL號碼: MFCD32693891
• 分類程式碼代碼: 12352125
• NACRES: NA.21

屬性

• ligand: pomalidomide
• 品質等級: 100
• 化驗: ≥95.0%
• 形狀: powder
• 官能基: azide
• 儲存溫度: 2-8°C
• SMILES 字串: [N-]=[N+]=NCCOCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3
• InChI 密鑰: NJPMWHWTBBYBDY-UHFFFAOYSA-N

描述

應用

Pomalidomide-PEG₁-C₂-azide is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Contains an alkyne, allowing for conjugation through click chemistry. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

其他說明

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable