929484

FBnG-C3-PEG₁-C3-NH₂ hydrochloride

≥95%

• 同義詞: (R)-2-acetamido-3-((2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)thio)-N-(3-(3-aminopropoxy)propyl)propanamide hydrochloride
• 經驗公式（希爾表示法）: C₂₃H₃₁FN₈O₄S · xHCl
• 分子量：: 534.61 (free base basis)
• 分類程式碼代碼: 12352101
• NACRES: NA.21

屬性

• 品質等級: 100
• 化驗: ≥95%
• 形狀: powder
• 官能基: amine
• 儲存溫度: 2-8°C
• SMILES 字串: O=C1NC(N)=NC2=C1N=C(SC[C@@H](C(NCCCOCCCN)=O)NC(C)=O)N2CC3=CC=C(C=C3)F.Cl

描述

應用

Protein degrader building block FBnG-C₃-PEG₁-C₃-NH₂ hydrochloride enables the synthesis of molecules for degradation of proteins and PROTAC^® (proteolysis-targeting chimeras) research. This conjugate contains a p-fluorobenzylguanine (FBnG) ligand, a PEG linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.


Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation



Protein Degrader Building Blocks

其他說明

Targeted Protein Degradation by Small Molecules

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable