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Merck
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Key Documents

929271

Sigma-Aldrich

EBX1-alkyne

≥95.0%

同義詞:

1-[4-(2-Propyn-1-yloxy)-1-butyn-1-yl]-1,2-benziodoxol-3(1H)-one

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About This Item

經驗公式(希爾表示法):
C14H11IO3
CAS號碼:
分子量::
354.14
分類程式碼代碼:
12352101
NACRES:
NA.22

品質等級

化驗

≥95.0%

形狀

powder

儲存溫度

−20°C

SMILES 字串

O=C(OI1C#CCCOCC#C)C2=C1C=CC=C2

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應用

EBX1-alkyne is a hypervalent iodine reagent used for labeling cysteines. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitative applications. The method uses light or heavy labeling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis. Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Eranthie Weerapana et al.
Nature, 468(7325), 790-795 (2010-11-19)
Cysteine is the most intrinsically nucleophilic amino acid in proteins, where its reactivity is tuned to perform diverse biochemical functions. The absence of a consensus sequence that defines functional cysteines in proteins has hindered their discovery and characterization. Here we

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