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Merck
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927317

Sigma-Aldrich

Linear polyethylenimine-block-poly(ethylene glycol)

PEG average Mn 750, PEI average Mn 15,000

同義詞:

PEG-b-PEI, PEG-PEI, poly(ethylene glycol)-block-polyethylenimine

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About This Item

線性公式:
CH3(C2H4O)n(C2H5N)mOH
分類程式碼代碼:
12162002
NACRES:
NA.21

形狀

solid

品質等級

分子量

PEG Mn 750 Da
PEG average Mn 750
PEI Mn 15,000 Da
PEI average Mn 15,000

顏色

white to yellow

儲存溫度

2-8°C

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應用

Due to their low immunogenicity profiles, polymeric nonviral vectors have shown promise in advancing the treatment of many severe genetic and acquired diseases via gene therapy. Poly(ethyleneimine) is one of the most commonly used cationic polymers for gene delivery applications. Copolymers of PEI and hydrophilic poly(ethylene glycol) have been designed to provide a stealth-like shield around polymer/DNA complexes, reducing nonspecific interactions, inhibiting activation of the reticuloendothelial system, and prolonging the half-life of the complexes in the blood.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Pallab Banerjee et al.
Bioconjugate chemistry, 17(1), 125-131 (2006-01-19)
A block copolymer of a hyperbranched poly(ethylene glycol)-like core and linear polyethylenimine (HBP) was synthesized by a facile synthetic route that included (1) a single-step cationic copolymerization of diepoxy and polyhydroxyl monomers, (2) derivatization of hydroxyl groups of the core

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