914746

Thiophosphoro alkyne dichloridate

≥95%

• 同義詞: O-(Prop-2-yn-1-yl) phosphorodichloridothioate, Chemoselective histidine labeling reagent, Phosphorodichloridothioate 2-propyn-1-ol, Propargyl thiophosphorodichloridate, TPAC, Thiophosphoro alkyne dichloridate, Thiophosphorodichloridate reagent, Thiophosphorus electrophile
• 經驗公式（希爾表示法）: C₃H₃Cl₂OPS
• CAS號碼: 21300-59-4
• 分子量：: 189.00
• MDL號碼: MFCD32857301
• 分類程式碼代碼: 12352106
• NACRES: NA.22

屬性

• 品質等級: 100
• 化驗: ≥95%
• 形狀: liquid
• 儲存溫度: −20°C
• SMILES 字串: [P](=S)(Cl)(Cl)OCC#C
• InChI: 1S/C3H3Cl2OPS/c1-2-3-6-7(4,5)8/h1H,3H2
• InChI 密鑰: HPJLQEFYLAALCL-UHFFFAOYSA-N

描述

應用

Thiophosphoro alkyne dichloridate (TPAC) is a histidine labeling reagent developed by the Chang lab that mimics native post-translational His phosphorylation. The alkyne allows for subsequent reactions or addition of payloads by copper-assisted alkyne-azide cycloaddition (CuAAC) chemistry. TPAC was also demonstrated to covalently modify His-tags, and by clicking on polyarginine tags, enabled protein delivery into live cells.

其他說明

Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: 175.8 °F
• 閃點（°C）: 79.9 °C