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Merck
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Key Documents

901397

Sigma-Aldrich

Poly(ethylene glycol) linear dendrimer

NHBoc terminated, PEG Mn 6000, generation 4

同義詞:

Dendron bifunctionalized PEG, PFD-G4-PEG6k-NHBoc, Polyethylene glycol

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About This Item

經驗公式(希爾表示法):
C678H1202N32O323
分子量::
14970.82
分類程式碼代碼:
51171641
NACRES:
NA.23

品質等級

形狀

solid

分子量

PEG Mn 6000

顏色

white to off-white

儲存溫度

−20°C

一般說明

  • Polymer architecture: Dendron-functionalized PEG
  • Generation: 4
  • PEG Average Mn: 6,000
  • End group functionality: Boc-protected amine
  • No. surface groups: 32
  • Calculated mol. wt.: 14970.98 g/mol
  • Boc: tert-Butyloxycarbonyl
  • Bis-MPA: 2,2-bis(hydroxymethyl)propionic acid

應用

Bis-MPA (or 2,2-bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. PEG-core dendrimers feature excellent solubility in water and a high degree of functionality per PEG chain, making them strong candidates for advanced drug delivery systems or as targeting vessels. Additionally, the terminal amine groups can readily be used in EDC or DCC coupling reactions (after Boc deprotection) with carbonyl-containing compounds, to yield highly functionalized materials for a variety of biomedical applications.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Yanjun Fu et al.
Bioconjugate chemistry, 17(4), 1043-1056 (2006-07-20)
The purpose of this study was to design, synthesize, and initially characterize a representative set of novel constructs for large-molecular radiographic/computed tomography (CT) contrast agents, intended for a primarily intravascular distribution. A new assembly of well-known and biocompatible components consists
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

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