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Merck
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Key Documents

901297

Sigma-Aldrich

Polyester bis-MPA dendron 4 NHBoc, 1 azide (core)

generation 2

同義詞:

Bis-MPA dendron, PFd-G2-Azide-NH-BOC

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About This Item

經驗公式(希爾表示法):
C53H89N7O22
分子量::
1176.31
分類程式碼代碼:
12352125
NACRES:
NA.23

描述

4 NHBoc, 1 azide (core)

品質等級

形狀

solid

分子量

generation 2

號表面基團

4

顏色

white to off-white

官能基

azide (core)

儲存溫度

−20°C

一般說明

  • Polymer architecture: Dendron
  • End Group Functionality: Boc-protected amine
  • Boc : tert-Butyloxycarbonyl
  • Bis-MPA : 2,2-Bis(hydroxymethyl)propionic acid.

應用

Bis-MPA (or 2,2-Bis(methylol)propionic acid) is an aliphatic, pro-chiral molecule comprised of two hydroxyls and one carboxylic group that has been used in the synthesis of many different types of polymers. Dendrons synthesized from bis-MPA are biodegradable and have low cytotoxicity, making them well suited for use in biological research applications. These materials have been used in many applications such as signal amplification in bioassays and in drug delivery applications. After Boc deprotection, amine-functionalized dendrons can be readily used in EDC or DCC coupling reactions with carbonyl-containing compounds to yield highly functionalized materials for a variety of biomedical applications. Additionally, the azide-core can be readily conjugated using either copper(I)-catalysed alkyne-azide cycloaddition (CuAAC) or strain-promoted alkyne-azide cycloaddition (SPAAC).

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

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