803928

4-(三氟甲基磺酰氧基)-3-(三甲基甲硅烷基)-5,6-二氢吡啶-1(2H)-羧酸苄酯

• 同義詞: Garg Azacyclohexyne Precursor
• 經驗公式（希爾表示法）: C₁₇H₂₂F₃NO₅SSi
• 分子量：: 437.51
• 分類程式碼代碼: 12352100
• PubChem物質ID: 329768833
• NACRES: NA.22

屬性

• 描述: FP: >230°F
• 形狀: liquid
• 折射率: n20/D 1.4902
• 密度: 1.2625 g/mL at 25 °C
• 官能基: fluoro; phenyl; triflate
• 儲存溫度: 2-8°C
• SMILES 字串: C[Si](C)(C)C1=C(OS(=O)(C(F)(F)F)=O)CCN(C(OCC2=CC=CC=C2)=O)C1
• InChI: 1S/C17H22F3NO5SSi/c1-28(2,3)15-11-21(16(22)25-12-13-7-5-4-6-8-13)10-9-14(15)26-27(23,24)17(18,19)20/h4-8H,9-12H2,1-3H3
• InChI 密鑰: QGKRRFLQHRMSAL-UHFFFAOYSA-N

描述

一般說明

Benzyl 4-(trifluoromethylsulfonyloxy)-3-(trimethylsilyl)-5,6-dihydropyridine-1(2H)-carboxylate is a silyl triflate. It can be prepared from 4-methoxypyridine, via a three-step route.

應用

Benzyl 4-(trifluoromethylsulfonyloxy)-3-(trimethylsilyl)-5,6-dihydropyridine-1(2H)-carboxylate may be used as a starting reagent for the synthesis of 3,4-piperidyne. 3,4-Piperidyne is a precursor for the synthesis of various functionalized heterocyclic compounds.

Building block is a precursor for a highly useful azacyclohexyne intermediate, which is generated in the presence of Cesium Fluoride. The azacyclohexyne can be trapped in situ with dipolariphiles and other dienes to form bicyclic carbocycles and heterocycles.

其他說明

Generation and Regioselective Trapping of a 3,4-Piperidyne for the Synthesis of Functionalized Heterocycles

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable