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Merck
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重要文件

771058

Sigma-Aldrich

4-(4′-Hydroxyphenylazo)benzoic acid

97%

同義詞:

(E)-4-[(4-Hydroxyphenyl)azo]benzoic acid

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About This Item

經驗公式(希爾表示法):
C13H10N2O3
CAS號碼:
分子量::
242.23
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.22

化驗

97%

形狀

solid

反應適用性

reagent type: cross-linking reagent

mp

270-280 °C

官能基

carboxylic acid
hydroxyl

儲存溫度

2-8°C

SMILES 字串

OC(C1=CC=C(/N=N/C2=CC=C(O)C=C2)C=C1)=O

InChI

1S/C13H10N2O3/c16-12-7-5-11(6-8-12)15-14-10-3-1-9(2-4-10)13(17)18/h1-8,16H,(H,17,18)/b15-14+

InChI 密鑰

HLVCZTOFOWHIJZ-CCEZHUSRSA-N

應用

4-(4′-Hydroxyphenylazo)benzoic acid may be used to synthesize 4-(4-propyloxyphenylazo)benzoic acid via Williamson synthesis by reacting with 1-bromopropane.
Azobenzene cleavable linker. Treatment with sodium dithionite (sodium hydrosulfite) reduces azo functionality, cleaving the N-N bond to yield two primary amines.
Has been used in proteomic and affinity chromatography applications.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Felicetta Landi et al.
Organic & biomolecular chemistry, 8(1), 56-59 (2009-12-22)
A new chemically-cleavable linker has been synthesised for the affinity-independent elution of biomolecules by classical affinity chromatography. This azo-based linker is shown to couple efficiently with "click" derivatised ligands such as biotin propargyl amide through a copper(I)-catalysed Huisgen 1,3-dipolar cycloaddition
A mild chemically cleavable linker system for functional proteomic applications.
Steven H L Verhelst et al.
Angewandte Chemie (International ed. in English), 46(8), 1284-1286 (2007-01-06)

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