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765090

Sigma-Aldrich

聚乙烯亚胺，线性

average Mn 10,000, PDI ≤1.3

同義詞:

PEI

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About This Item

線性公式:
(CH2CH2NH)n
CAS號碼:
9002-98-6
MDL號碼:
MFCD00039669
分類程式碼代碼:
12162002
NACRES:
NA.23

形狀

solid

品質等級

100

分子量

average Mn 10,000

mp

48-53 °C

蛋白質二硫鍵異構酶

≤1.3

儲存溫度

2-8°C

SMILES 字串

N1CC1

InChI

1S/C2H5N/c1-2-3-1/h3H,1-2H2

InChI 密鑰

NOWKCMXCCJGMRR-UHFFFAOYSA-N

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相關類別

一般說明

聚乙烯亚胺（线性）是一种用途广泛的阳离子聚合物，具有较高的转染效率。它可用作基因传递试剂。这是一种非脂质聚阳离子，可用于将寡核苷酸和质粒转染至体内和体外细胞。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319

危險分類

Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number
MKCH4846
MKCF0987
MKCC1827
MKBV9404V
MKBR2633V

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Bromodomain and extra-terminal (BET) protein inhibitors suppress chondrocyte differentiation and restrain bone growth
Niu N, et al.
The Journal of biological chemistry, 291(52), 26647-26657 (2016)
Systemic linear polyethylenimine (L-PEI)-mediated gene delivery in the mouse
Zou S, et al.
The journal of gene medicine, 2(2), 128-134 (2000)
A comparison of linear and branched polyethylenimine (PEI) with DCChol/DOPE liposomes for gene delivery to epithelial cells in vitro and in vivo
Wiseman JW, et al.
Gene Therapy, 10(19), 1654-1654 (2003)
Marie-Elise Bonnet et al.
Pharmaceutical research, 25(12), 2972-2982 (2008-08-19)
The success of nucleic acid therapies depends upon delivery vehicle's ability to selectively and efficiently deliver therapeutic nucleic acids to target organ with minimal toxicity. The cationic polymer polyethylenimine (PEI) has been widely used for nucleic acid delivery due to
Dae Hee Lee et al.
Biomaterials, 171, 34-45 (2018-04-22)
Limitation of current anti-Vascular Endothelial Growth Factor (VEGF) cancer therapy is transitory responses, inevitable relapses and its insufficient tumor-targeting. Thus, multifaceted approaches, including the development of bispecific antibodies and combination strategies targeting different pathways have been proposed as an alternative.
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Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting

Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.

Functionalized PEI and Its Role in Gene Therapy

Gene therapy has become one of the most discussed techniques in biomedical research in recent years.

Functional Polymers for Biomedical Applications

Wide range of functional polymers for biomedical applications have been synthesized and structurally characterized. Several classes of polymers including biodegradable polymers, hydrophilic & amphiphilic polymers, and stimuli responsive polymers have been prepared using controlled and directed functionalization via "living" polymerization such as RAFT, ionic and ring opening polymerization. Selected polymers have been studied for their structure-properties relationship. "

Global Trade Item Number

庫存單位GTIN
765090-1G4061835508716

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