跳轉至內容
Merck
全部照片(1)

重要文件

536822

Sigma-Aldrich

PAMAM-OH 树枝状聚合物,第6代 溶液

5 wt. % in methanol

登入查看組織和合約定價


About This Item

線性公式:
[NH2(CH2)2NH2]:(G=6);dendri PAMAM(NHCH2CH2OH)256
分子量::
58298.21
MDL號碼:
分類程式碼代碼:
12162002
NACRES:
NA.25

描述

amidoethanol surface groups

品質等級

形狀

liquid

分子量

generation 6

特點

core type ethylenediamine core (2-carbon core)

濃度

5 wt. % in methanol

號表面基團

256

折射率

n20/D 1.336

密度

0.807 g/mL at 25 °C

儲存溫度

2-8°C

一般說明

PAMAM-OH (poly(amidoamine) dendrimers are highly branched core-shell nanostructures with surface hydroxyl groups. The presence of hydroxyl groups on the surface of the PAMAM-OH dendrimer molecule leads to stronger interaction with the components of the cell membrane via the formation of hydrogen bonds. This type of interaction can modify the properties and function of cell membranes. PAMAM-OH dendrimers also have an advantage over PAMAM dendrimers in terms of cytotoxicity and aggregation problems because of the absence of amine functionality.

應用

PAMAM-OH dendrimer can be used to formulate poorly water-soluble drugs to increase water solubility, and therefore enhance the bioavailability of these drugs. It can also be applied to catalysts and organic molecules, where dendrimers function as solubility enhancers and modifiers.

外觀

含有 256 个表面羟基。

法律資訊

Dendritech®, Inc. 制造
使用及制造受 Dow Chemical Company 拥有的专利所保护。
Dendritech is a registered trademark of Dendritech, Inc.

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

標靶器官

Eyes

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

51.8 °F - closed cup

閃點(°C)

11 °C - closed cup


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

未看到正確版本?

如果您需要一個特定的版本,您可以透過批號來尋找特定憑證。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Comparative pharmacokinetics of PAMAM-OH dendrimers and HPMA copolymers in ovarian tumor-bearing mice
Sadekar S, et al.
Drug delivery and translational research, 3(3), 260-271 (2013)
The influence of PAMAM-OH dendrimers on the activity of human erythrocytes ATPases
Ciolkowski M, et al.
Biochimica et Biophysica Acta - Biomembranes, 1808(11), 2714-2723 (2011)
Polyplexes assembled with internally quaternized PAMAM-OH dendrimer and plasmid DNA have a neutral surface and gene delivery potency
Lee Jung Hoon, et al.
Bioconjugate Chemistry, 14(6), 1214-1221 (2003)

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務