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Merck
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Key Documents

426091

Sigma-Aldrich

2,5-二羟基苯甲酸甲酯

99%

同義詞:

龙胆酸甲酯

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About This Item

線性公式:
(HO)2C6H3CO2CH3
CAS號碼:
分子量::
168.15
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

99%

mp

86-88 °C (lit.)

SMILES 字串

COC(=O)c1cc(O)ccc1O

InChI

1S/C8H8O4/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4,9-10H,1H3

InChI 密鑰

XGDPKUKRQHHZTH-UHFFFAOYSA-N

一般說明

Methyl 2,5-dihydroxybenzoate (methyl gentisate) is an alkyl ester of gentisic acid. It is reported to show less cytotoxic and mutagenic activity than hydroquinone with a potential to inhibit melanogenesis. It has been synthesized from 2,5-dihydroxybenzoic acid. The crystal structure of the molecule was found to be planar.

應用

Methyl 2,5-dihydroxybenzoate (methyl gentisate) may be used as a starting material in the synthesis of euonyminol.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Total Synthesis of (.+-.)-Euonyminol, the Sesquiterpenoid Nucleus of Cathedulin K-19, via an Epoxide Cascade Cyclization.
White JD, et al.
Journal of the American Chemical Society, 117(38), 9780-9781 (1995)
E V Curto et al.
Biochemical pharmacology, 57(6), 663-672 (1999-02-26)
To discover safe and effective topical skin-lightening agents, we have evaluated alkyl esters of the natural product gentisic acid (GA), which is related to our lead compound methyl gentisate (MG), and four putative tyrosinase inhibitors, utilizing mammalian melanocyte cell cultures
Methyl 2, 5-dihydroxybenzoate.
Brown CL, et al.
Acta Crystallographica Section E, Structure Reports Online, 59(5), 630-631 (2003)

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