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379115

Sigma-Aldrich

N,N′-二环己基碳二亚胺 溶液

1.0 M in methylene chloride, for peptide synthesis

同義詞:

DCC

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About This Item

線性公式:
C6H11N=C=NC6H11
CAS號碼:
538-75-0
分子量：:
206.33
MDL號碼:
MFCD00011659
分類程式碼代碼:
12352111
PubChem物質ID:
24863614
NACRES:
NA.22

產品名稱

N,N′-二环己基碳二亚胺 溶液, 1.0 M in methylene chloride

形狀

liquid

品質等級

200

反應適用性

reaction type: Coupling Reactions

濃度

1.0 M in methylene chloride

密度

1.247 g/mL at 25 °C

應用

peptide synthesis

SMILES 字串

C1CCC(CC1)N=C=NC2CCCCC2

InChI

1S/C13H22N2/c1-3-7-12(8-4-1)14-11-15-13-9-5-2-6-10-13/h12-13H,1-10H2

InChI 密鑰

QOSSAOTZNIDXMA-UHFFFAOYSA-N

基因資訊

human ... EPHX2(2053)
mouse ... Ephx2(13850)

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相關類別

應用

DCC（ N ， N ′）-二环己基碳二亚胺）主要用于介导肽偶联 ，也可活化羧酸进行酯化。

訊號詞

Danger

危險分類

Acute Tox. 4 Dermal - Carc. 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

個人防護裝備

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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分析證明 (COA)

Lot/Batch Number
MKCQ3725
MKCN6433
MKCM2709
MKCL3517
MKCJ0017

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Effects of amounts of additives on peptide coupling mediated by a water?soluble carbodiimide in alcohols.
Nozaki S.
The Journal of Peptide Research, 54(2), 162-167 (1999)
Liposomes containing alkylated methotrexate analogues for phospholipase A 2 mediated tumor targeted drug delivery.
Kaasgaard T, et al.
Chemistry and Physics of Lipids, 157(2), 94-103 (2009)
Denys Pogoryelov et al.
Nature chemical biology, 6(12), 891-899 (2010-10-26)
The microscopic mechanism of coupled c-ring rotation and ion translocation in F(1)F(o)-ATP synthases is unknown. Here we present conclusive evidence supporting the notion that the ability of c-rings to rotate within the F(o) complex derives from the interplay between the
Masashi Toei et al.
The Journal of biological chemistry, 288(36), 25717-25726 (2013-07-31)
N,N-Dicyclohexylcarbodiimide (DCCD) is a classical inhibitor of the F0F1-ATP synthase (F0F1), which covalently binds to the highly conserved carboxylic acid of the proteolipid subunit (c subunit) in F0. Although it is well known that DCCD modification of the c subunit
Kenji Mizutani et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(33), 13474-13479 (2011-08-05)
The prokaryotic V-ATPase of Enterococcus hirae, closely related to the eukaryotic enzymes, provides a unique opportunity to study the ion-translocation mechanism because it transports Na(+), which can be detected by radioisotope (22Na(+)) experiments and X-ray crystallography. In this study, we
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文章

碳二亚胺介导的肽偶联

碳二亚胺介导的肽偶联仍然是目前最常用的技术。

Carbodiimide-mediated peptide coupling

Carbodiimide-mediated peptide coupling remains to the most frequently used technique.

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