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文件

369799

Sigma-Aldrich

(叔丁氧基羰基亚甲基)三苯基磷烷

98%

同義詞:

三苯基磷乙酸叔丁酯

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About This Item

線性公式:
(C6H5)3P=CHCO2C(CH3)3
CAS號碼:
分子量::
376.43
EC號碼:
MDL號碼:
分類程式碼代碼:
12352108
PubChem物質ID:
NACRES:
NA.22

化驗

98%

形狀

solid

反應適用性

reaction type: C-C Bond Formation

mp

152-155 °C (lit.)

儲存溫度

2-8°C

SMILES 字串

CC(C)(C)OC(=O)C=P(c1ccccc1)(c2ccccc2)c3ccccc3

InChI

1S/C24H25O2P/c1-24(2,3)26-23(25)19-27(20-13-7-4-8-14-20,21-15-9-5-10-16-21)22-17-11-6-12-18-22/h4-19H,1-3H3

InChI 密鑰

ZWZUFQPXYVYAFO-UHFFFAOYSA-N

應用

用于合成醛糖还原酶抑制剂、鬼臼毒素衍生物和互变霉素的 Wittig 试剂。
药物化学中的多功能 Wittig 试剂。

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1 - STOT RE 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


分析證明 (COA)

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The Journal of Organic Chemistry, 57, 2922-2922 (1992)
George Kokotos et al.
Journal of medicinal chemistry, 47(14), 3615-3628 (2004-06-25)
The Group IVA cytosolic phospholipase A(2) (GIVA PLA(2)) is a particularly attractive target for drug development because it is the rate-limiting provider of proinflammatory mediators. We previously reported the discovery of novel 2-oxoamides that inhibit GIVA PLA(2) [Kokotos, G.; et
Tetrahedron Letters, 35, 4809-4809 (1994)
B L Mylari et al.
Journal of medicinal chemistry, 35(12), 2155-2162 (1992-06-12)
Benzothiazole side chains featured in zopolrestat (1a) and its congeners were incorporated into oxophthalazineacetic acid replacements, including indazole, pyridazinone, and pyridopyridazinone with a pendant acetic acid moiety. Potent aldose reductase inhibition activity among resulting compounds is as widespread as it
Fritz Sieber et al.
Phosphorus, sulfur, and silicon and the related elements, 180(3-4), 647-657 (2006-02-24)
Elemental selenium generated by the photobleaching of selenomerocyanine dyes forms conjugates with serum albumin and serum lipoproteins that are toxic to leukemia and selected solid tumor cells but well tolerated by normal CD34-positive hematopoietic stem and progenitor cells. Serum albumin

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