跳轉至內容
Merck
全部照片(1)

Key Documents

365645

Sigma-Aldrich

穿心莲内酯

98%

同義詞:

穿心莲内酯, 脱水穿心莲内酯

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C20H30O5
CAS號碼:
分子量::
350.45
Beilstein:
42762
EC號碼:
MDL號碼:
分類程式碼代碼:
12352005
PubChem物質ID:
NACRES:
NA.22

品質等級

化驗

98%

形狀

powder

光學活性

[α]20/D −126°, c = 1.5 in acetic acid

mp

229-232 °C (lit.)

官能基

ester
hydroxyl

SMILES 字串

C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H](C\C=C3/[C@H](O)COC3=O)C(=C)CC[C@H]12

InChI

1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1

InChI 密鑰

BOJKULTULYSRAS-OTESTREVSA-N

尋找類似的產品? 前往 產品比較指南

一般說明

穿心莲内酯是一种具有生物活性的二萜内酯,是传统药物穿心莲的主要成分。已知其具有不同的生物活性,如抗炎、抗疟疾、抗癌 和保肝活性。对登革病毒也表现出强效的抗病毒作用。

應用


  • Andrographolide-based drug candidate against Keap1-Nrf2 pathway through rigorous cheminformatics screening.: This study identifies potential andrographolide derivatives as innovative drug candidates that target the Keap1-Nrf2 pathway, crucial for antioxidant defense mechanisms. This approach highlights the compound′s versatility in developing treatments that could mitigate oxidative stress-related diseases, making it a significant area of interest for chemists and material scientists in both academia and biotech sectors (Jain and Sudandira Doss, 2023).

  • TMT-based quantitative proteomics reveals the targets of andrographolide on LPS-induced liver injury.: This investigation into the proteomic changes induced by andrographolide in liver injury models offers insights into its therapeutic mechanisms, highlighting its potential as a treatment for inflammation and liver diseases, relevant for research and development in pharmaceutical and biochemical fields (Ge et al., 2023).

  • Investigation of targets and anticancer mechanisms of covalently acting natural products by functional proteomics.: This study evaluates andrographolide′s roles within the context of its anticancer properties, providing a detailed analysis of its interactions at the molecular level, essential for material scientists and chemists working on novel cancer therapies (Zhao et al., 2023).

生化/生理作用

具有抗炎特性的双萜内酯。它可阻断外源刺激下的 T 细胞增殖和补体诱导的巨噬细胞趋化迁移。可阻断几种癌细胞系的体外增殖。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

未看到正確版本?

如果您需要一個特定的版本,您可以透過批號來尋找特定憑證。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

In vitro and in vivo anti-inflammatory effects of andrographolide.
Abu-Ghefreh Ala'AA, et al.
International Immunopharmacology, 9(3), 313-318 (2009)
Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride.
Handa SS and Sharma A.
The Indian Journal of Medical Research, 92, 276-283 (1990)
Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata.
Rajagopal S, et al.
Journal of Experimental Therapeutics & Oncology, 3(3), 147-158 (2003)
Activity of andrographolide against dengue virus.
Panraksa P, et al.
Antiviral Research, 139, 69-78 (2017)
Wan J Lu et al.
Biochemical pharmacology, 84(7), 914-924 (2012-07-10)
Andrographolide, a novel nuclear factor-κB (NF-κB) inhibitor, is isolated from leaves of Andrographis paniculata. Platelet activation is relevant to a variety of coronary heart diseases. Our recent studies revealed that andrographolide possesses potent antiplatelet activity by activating the endothelial nitric

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務