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Merck
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重要文件

361275

Sigma-Aldrich

3′-脱氧-3′-氟胸苷

97%

同義詞:

3′-Fluoro-2′,3′-dideoxythymidine, 3′-Fluorodeoxythymidine

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About This Item

經驗公式(希爾表示法):
C10H13FN2O4
CAS號碼:
分子量::
244.22
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.22

品質等級

化驗

97%

形狀

solid

mp

176-178 °C (lit.)

儲存溫度

2-8°C

SMILES 字串

CC1=CN([C@H]2C[C@H](F)[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13FN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h3,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6-,7+,8+/m0/s1

InChI 密鑰

UXCAQJAQSWSNPQ-XLPZGREQSA-N

基因資訊

human ... TK2(7084)

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應用

具有应用前景的抗病毒试剂,活性类似于其他 3′-脱氧-3′-取代胸苷。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Eliot T McKinley et al.
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Positron emission tomography (PET) with the thymidine analogue [(18)F]fluorothymidine ([(18)F]FLT) has been shown to detect early response to chemotherapy in high-grade lymphoma. In this preclinical in vitro and in vivo study we compared [(18)F]FLT to the glucose analogue [(18)F]fluorodeoxyglucose ([(18)F]FDG)
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Clinical nuclear medicine, 37(11), 1058-1064 (2012-10-03)
The aim was to assess the value of tumor lesion glycolysis (TLG) and tumor lesion proliferation (TLP) determined by FDG and 3'-deoxy-3'-F-fluorothymidine (FLT) PET for response prediction and prognostic differentiation in patients with advanced non-small cell lung cancer (NSCLC) treated

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