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211370

Sigma-Aldrich

磺酰胺

99%

同義詞:

磺酰二胺, 磺酰胺, 酰亚胺氨基磺酸

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About This Item

線性公式:
(NH2)2SO2
CAS號碼:
分子量::
96.11
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

99%

mp

90-92 °C (lit.)

溶解度

water: soluble 50 mg/mL, clear, colorless to faintly yellow

密度

1.611 g/mL at 25 °C (lit.)

SMILES 字串

NS(N)(=O)=O

InChI

1S/H4N2O2S/c1-5(2,3)4/h(H4,1,2,3,4)

InChI 密鑰

NVBFHJWHLNUMCV-UHFFFAOYSA-N

基因資訊

human ... CA1(759) , CA2(760)

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一般說明

磺酰胺,一种与格氏试剂相容的极性非质子溶剂,可用作医学化学中的官能团。

應用

磺胺被用于合成以下物质:
  • ArCH=NSO2NH2型席夫碱
  • 1H,3H-2,1,3-苯并噻二嗪-4-酮-2,2-二氧化物(BTDD)
  • 在一项PPARα激活的研究中,合成油酰乙醇胺类似物的磺酰胺类似物。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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Anna Di Fiore et al.
Bioorganic & medicinal chemistry letters, 20(12), 3601-3605 (2010-05-18)
We investigated the inhibition of carbonic anhydrase (CA, EC 4.2.1.1) isoforms I-XV with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylsulfamide and other simple or sugar sulfamides, a class of less investigated CA inhibitors (CAIs). The crystal structure of the adduct of hCA II with the boron-substituted
A Scozzafava et al.
Journal of enzyme inhibition, 15(5), 443-453 (2000-10-13)
Sulfamide and sulfamic acid are the simplest compounds containing the SO2NH2 moiety, responsible for binding to the Zn(II) ion within carbonic anhydrase (CA, EC 4.2.1.1) active site, and thus acting as inhibitors of the many CA isozymes presently known. Here
Carolina Cano et al.
Journal of medicinal chemistry, 50(2), 389-393 (2007-01-19)
Long chain saturated and unsaturated alkyl sulfamide and propyl sulfamide derivatives, analogs of oleoylethanolamide, have been synthesized and evaluated in vivo and in vitro as peroxisome proliferator activated receptor alpha (PPARalpha) activators. Additionally, the anorexic effects of the new compounds
Bacterial cleavage of nitrogen to sulfone bonds in sulfamide and 1H-2, 1, 3-benzothiadiazin-4 (3H)-one 2, 2-dioxide: formation of 2-nitrobenzamide by Gordonia sp.
Rein U and Cook AM.
FEMS Microbiology Letters, 172(2), 107-113 (1999)
Alessio Innocenti et al.
Bioorganic & medicinal chemistry letters, 19(4), 1155-1158 (2009-01-09)
The membrane-associated mouse isozyme of carbonic anhydrase XV (mCA XV), has been investigated for its interaction with anion inhibitors. mCA XV is an isoforms possessing a very particular inhibition profile by anions, dissimilar to that of all other mammalian CAs

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