SHH
sonic hedgehog
同義詞:
HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS
物種:
Human SHH (6469), Mouse Shh (20423), Rat Shh (29499), chicken SHH (395615), domestic cat SHH (100169727), dog SHH (608860), cow SHH (286821), sheep SHH (780492), sheep SHH (101117666), domestic guinea pig Shh (100732014) ...更多
UniProtKB ID:
基因 ID:
- Human(6469) Summary: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]
- Mouse(20423) sonic hedgehog
- Rat(29499) sonic hedgehog
- chicken(395615) sonic hedgehog
- domestic cat(100169727) sonic hedgehog
- dog(608860) sonic hedgehog
- cow(286821) sonic hedgehog
- sheep(780492) sonic hedgehog
- sheep(101117666) sonic hedgehog
- domestic guinea pig(100732014) sonic hedgehog
- naked mole-rat(101719896) sonic hedgehog
- Domestic Rabbit(100352774) sonic hedgehog
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ELISA
Antibodies
產品編號
描述
物種活性
應用
Anti-Sonic Hedgehog Antibody, from rabbit, purified by affinity chromatography,
物種活性
human, mouse
應用
immunohistochemistry
western blot
western blot
Anti-SHH, affinity isolated antibody,
物種活性
dog, guinea pig, horse, human, mouse, rabbit, rat
應用
immunohistochemistry
western blot
western blot
Anti-Sonic Hedgehog peptide (C-terminal) antibody produced in goat, affinity isolated antibody, lyophilized powder,
物種活性
mouse
應用
immunohistochemistry
western blot
western blot
Monoclonal Anti-Sonic Hedgehog (N-terminal) antibody produced in rat, clone 171018, purified immunoglobulin, lyophilized powder,
物種活性
human, mouse
應用
ELISA
immunohistochemistry
neutralization
western blot
immunohistochemistry
neutralization
western blot
Monoclonal Anti-Sonic Hedgehog (Shh) 小鼠抗, clone SH154, purified from hybridoma cell culture,
物種活性
human, mouse, rat
應用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
產品編號
描述
物種
Sonic Hedgehog human, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
物種
human
Sonic Hedgehog Peptide from mouse, ≥97% (SDS-PAGE), recombinant, expressed in E. coli, Fused to a histidine tag at the C-terminus, lyophilized powder,
物種
mouse