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Merck

GRM1

glutamate receptor, metabotropic 1

同義詞:
GPRC1A, MGLU1, MGLUR1, SCAR13
物種:
UniProtKB ID:
基因 ID:
  • Human(2911) Summary: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
  • Mouse(14816) glutamate receptor, metabotropic 1
  • Rat(24414) glutamate receptor, metabotropic 1
  • domestic guinea pig(100730891) glutamate receptor, metabotropic 1
  • naked mole-rat(101712477) glutamate receptor, metabotropic 1
  • Domestic Rabbit(100356201) glutamate receptor, metabotropic 1
  • Zebrafish(100150246) glutamate receptor, metabotropic 1
  • dog(484024) glutamate receptor, metabotropic 1
  • domestic cat(101094104) glutamate receptor, metabotropic 1
  • cow(540485) glutamate receptor, metabotropic 1
  • Horse(100060603) glutamate receptor, metabotropic 1
  • chicken(421614) glutamate receptor, metabotropic 1

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Small Molecule - Agonist

產品編號
描述
物種
(S)-3,5-二羟基苯基甘氨酸 水合物, ≥98% (HPLC), powder,
物種
human
鹅膏氨酸, ~95%, solid,
物種
rat
D-2-Aminoadipic acid, ,
物種
rat
L -2-氨基己二酸, ≥98% (TLC),
物種
rat, human
使君子氨酸, powder,
物種
rat

Small Molecule - Antagonist

產品編號
描述
物種
(+)-α-Methyl-4-carboxyphenylglycine, solid,
物種
rat
SIB 1757, ≥99% (HPLC), crystalline,
物種
human
AIDA, solid,
物種
rat, human
SIB 1893, >99%, solid,
物種
human
D-2-Aminoadipic acid, ,
物種
rat

Antibodies

產品編號
描述
物種活性
應用
单克隆抗 谷氨酸盐 小鼠抗, clone GLU-4, ascites fluid,
物種活性
wide range
應用
ELISA
Anti-Metabotropic Glutamate Receptor 1α Antibody, pain, CT, Chemicon®, from rabbit,
物種活性
human, monkey, rat
應用
immunohistochemistry
western blot
Anti-Metabotropic Glutamate Receptor 1 Antibody, Chemicon®, from rabbit,
物種活性
human
應用
immunohistochemistry
Anti-mGluR1 Antibody, Upstate®, from rabbit,
物種活性
rat
應用
western blot
Anti-Glutamate Receptor 1A, Metabotropic (mGluR1A) antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
物種活性
feline, mouse, rat
應用
immunohistochemistry
western blot

Small Molecule - Inhibitor

產品編號
描述
物種
L -2-氨基己二酸, ≥98% (TLC),
物種
rat, human
使君子氨酸, powder,
物種
rat
L-(+)-2-氨基-4-膦酰基丁酸, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
物種
rat, human
氨甲基膦酸, 99%,
物種
rat, human
L-谷氨酸, ReagentPlus®, ≥99% (HPLC),
物種
rat, human

Small Molecule - Mixed Agonist/Antagonist

產品編號
描述
物種
L-(+)-2-氨基-4-膦酰基丁酸, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
物種
rat, human
(±)-AMPA, solid,
物種
rat
L-谷氨酸, ReagentPlus®, ≥99% (HPLC),
物種
rat, human
L-谷氨酸, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
物種
rat, human
L-谷氨酸, BioUltra, ≥99.5% (NT),
物種
rat, human