Skip to Content
Merck
All Photos(1)

Key Documents

00922

Supelco

Difluoroacetic acid

for LC-MS LiChropur, ≥97.5% (GC)

Synonym(s):

DFA

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
F2CHCO2H
CAS Number:
Molecular Weight:
96.03
Beilstein:
1098588
MDL number:
UNSPSC Code:
41116004
NACRES:
NB.21

Assay

≥97.5% (GC)
97.5-102.5% (T)

technique(s)

LC/MS: suitable

refractive index

n20/D 1.344 (lit.)

bp

132-134 °C (lit.)

mp

−1 °C (lit.)

density

1.526 g/mL at 25 °C (lit.)

cation traces

Al: ≤5 ppm
Ca: ≤20 ppm
Cu: ≤5 ppm
Fe: ≤2 ppm
K: ≤50 ppm
Mg: ≤5 ppm
Na: ≤50 ppm

suitability

passes test for LC-MS

SMILES string

OC(=O)C(F)F

InChI

1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)

InChI key

PBWZKZYHONABLN-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Compared to trifluoroacetic acid (TFA), difluoroacetic acid (DFA) exhibits an improved sensitivity in mass spectral detection (ESI) as it has a reduced effect on ion suppression in reversed-phase liquid chromatography (RPLC-MS), while keeping its strong chromatographic performance enhancing effects.

Difluoroaceticacid is used in liquid chromatography-mass spectrometry applications. It is a volatile, low molecular-weight organic acid that improves the ionization and resolution of many molecules.

Application

Difluoroacetic acid can be used as an:
  • Acidifier in liquid chromatography (LC) experiments.
  • Ion-pairing agent in the HILIC-MS (hydrophilic interaction liquid chromatography-mass spectrometry) analysis of intact pharmaceutical glycoproteins.

Recommended products

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

172.4 °F - closed cup

Flash Point(C)

78 °C - closed cup


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Articles

Ultra-high performance liquid chromatographic (UHPLC) separation of polar herbicides, paraquat and diquat using SupelTM Carbon LC column with baseline resolution, excellent peak shape, and good lot-to-lot reproducibility.

Protocols

Reversed-Phase HPLC Analysis of Insulin Variants and Analogs by UV and Mass Spectral Detection

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service