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SML3020

Sigma-Aldrich

Taltirelin acetate

≥98% (HPLC)

Synonym(s):

(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-L-prolinamide, (S)-N-((S)-1-((S)-2-Carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)-1-methyl-2,6-dioxohexahydropyrimidine-4-carboxamide, (S)-N-[(Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-L-prolinamide, TA 0910, TA-0910, TA0910

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About This Item

Empirical Formula (Hill Notation):
C17H23N7O5 · xC2H4O2
Molecular Weight:
405.41 (free base basis)
UNSPSC Code:
12352107
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to off-white

storage temp.

−20°C

Biochem/physiol Actions

Taltirelin (TA-0910) is a thyrotropin-releasing hormone (TRH) mimetic with greatly enhanced brain-penetration, oral activity and stability. Taltirelin shortens the duration of pentobarbital-induced sleep (0.3-3 mg/kg po. or 0.03-0.3 mg/kg iv.), antagonizes reserpine-induced hypothermia (1 or 3 mg/kg po. or 0.1-0.3 mg/kg ip.), and enhances the spontaneous motor activity (30 mg/kg po.) in mice in vivo, while TRH produces these effects at about 100 times higher doses.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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M Yamamura et al.
Japanese journal of pharmacology, 53(4), 451-461 (1990-08-01)
Effects of orally administered TA-0910, a new thyrotropin-releasing hormone (TRH) analog, on the central nervous system (CNS) were investigated and compared with those of TRH. TA-0910 shortened the duration of pentobarbital-induced sleep and antagonized reserpine-induced hypothermia at 0.3 mg/kg or

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