SML3006
ICCB-19 Hydrochloride
≥98% (HPLC)
Synonym(s):
N-Cycloheptyl-2-[(4,5-dihydro-1H-imidazol-2-yl)thio]acetamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C12H21N3OS · HCl
CAS Number:
Molecular Weight:
291.84
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(NC1CCCCCC1)CSC2=NCCN2.Cl
Biochem/physiol Actions
ICCB-19 is a cell penetrant apoptosis inhibitor that activates autophagy leading to restoration of cellular homeostasis in cells with accumulated mutant tau, α-synuclein, or huntingtin. ICCB-19 potently and selectively inhibits TRADD. It binds to the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apparently ICCB-19 releases cIAP1/2 or TRAF2 from TRADD thus promoting the K63-linked ubiquitination of beclin 1.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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