SML2541

JWG-071

≥98% (HPLC)

• Synonym(s): 11-(sec-butyl)-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one, 5,11-Dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl-11-(1-methylpropyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
• Empirical Formula (Hill Notation): C₃₄H₄₄N₈O₃
• CAS Number: 2250323-50-1
• Molecular Weight: 612.76
• MDL number: MFCD32690071
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: N6(CCN(CC6)C)C1CCN(CC1)C(=O)c2cc(c(cc2)Nc3nc4[n](c5c([c]([n](c4cn3)C)=O)cccc5)C(CC)C)OC
• InChI: 1S/C34H44N8O3/c1-6-23(2)42-28-10-8-7-9-26(28)33(44)39(4)29-22-35-34(37-31(29)42)36-27-12-11-24(21-30(27)45-5)32(43)41-15-13-25(14-16-41)40-19-17-38(3)18-20-40/h7-12,21-23,25H,6,13-20H2,1-5H3,(H,35,36,37)
• InChI key: ACWOMSOYIIVIRV-UHFFFAOYSA-N

Description

Biochem/physiol Actions

JWG-071 is a selective inhibitor of ERK5 (MAPK7) and LRRK2 with an IC₅₀ value of 88nM for ERK5 inhibition and 109 nM for LRRK2 inhibition.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable