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SML2169

Sigma-Aldrich

Diphenidol hydrochloride

≥98% (HPLC)

Synonym(s):

α,α-Diphenyl-1-piperidinebutanol hydrochloride, Diphenyl(3-(1-piperidyl)propyl)carbinol hydrochloride, 1,1-Diphenyl-4-piperidino-1-butanol, Difenidol

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About This Item

Empirical Formula (Hill Notation):
C21H27NO · HCl
CAS Number:
3254-89-5
Molecular Weight:
345.91
EC Number:
221-850-0
MDL number:
MFCD00151479
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

Cl.OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3

InChI

1S/C21H27NO.ClH/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22;/h1-2,4-7,11-14,23H,3,8-10,15-18H2;1H

InChI key

AVZIYZHXZAYGJS-UHFFFAOYSA-N

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Biochem/physiol Actions

Diphenidol is a non-selective muscarinic acetylcholine receptor antagonist. Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lin Zhang et al.
Forensic science, medicine, and pathology, 11(4), 570-576 (2015-10-21)
Diphenidol hydrochloride (DPN), a nonphenothiazinic antiemetic agent used primarily in patients with Meniere disease and labyrinthopathies to treat vomiting and vertigo, is considered to be a relatively safe drug. Since it was first approved in the United States in 1967
Yu-Wen Chen et al.
Neuroscience letters, 552, 62-65 (2013-08-07)
Diphenidol has been shown to block voltage-gated Na(+) channels, which are associated with specific types of pain. Here, we evaluated the effects of diphenidol on chronic constriction injury (CCI)-evoked allodynia and expression of tumor necrosis factor-α (TNF-α). A peripheral nerve

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