SML0088

WZ811

≥98% (HPLC)

• Synonym(s): N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
• Empirical Formula (Hill Notation): C₁₈H₁₈N₄
• CAS Number: 55778-02-4
• Molecular Weight: 290.36
• MDL number: MFCD18086914
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825148
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥7 mg/mL
• storage temp.: 2-8°C
• SMILES string: C(Nc1ccccn1)c2ccc(CNc3ccccn3)cc2
• InChI: 1S/C18H18N4/c1-3-11-19-17(5-1)21-13-15-7-9-16(10-8-15)14-22-18-6-2-4-12-20-18/h1-12H,13-14H2,(H,19,21)(H,20,22)
• InChI key: KBVFRXIGQQRMEF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

WZ811 is a CXCR4 Antagonist

WZ811 is a potent, specific antagonist of CXCR4 (IC50 = 0.3 nM). WZ811 blocks SDF-1 mediated changes in cellular cAMP levels in U87 glioma cells (IC50 = 1.2 nM) and Matirgel infiltration of MDA-MB-231 cells (IC50 = 5.2 nM).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H315,H319,H335
• Precautionary Statements: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable