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Key Documents

SAB4300883

Sigma-Aldrich

Anti-NeuN antibody produced in rabbit

affinity isolated antibody

Synonym(s):

FLJ56884, FLJ58356, FOX3, HRNBP3, RBFOX3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

34 kDa

species reactivity

human, mouse, rat

concentration

1.0 mg/mL

technique(s)

western blot: 1:500-1:2000 (Cell Lysate)

isotype

IgG

accession no.

NP_001076044.1

UniProt accession no.

A6NFN3

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RBFOX3(146713)

General description

NeuN (neuronal nuclei), also known as RBFOX3 (RNA binding protein, fox-1 homolog 3), is encoded by the gene mapped to human chromosome 17q25.3. The encoded protein belongs to the RBFOX family of proteins. NeuN is present in nuclei and perinuclear cytoplasm of most of the neurons in the central nervous system (CNS) of mammals.

Specificity

The antibody detects endogenous level of total NeuN protein.

Immunogen

Recombinant protein of human NeuN.

Application

Anti-NeuN antibody produced in rabbit has been used in Immunohistochemical staining.

Biochem/physiol Actions

NeuN (neuronal nuclei)/RBFOX3 (RNA binding protein, fox-1 homolog 3) is a RNA splicing factor. It controls neuronal splicing pathway. NeuN is used as a potential marker of postmitotic neurons in studies of neuronal differentiation and in the evaluation of neuronal status both in norm and pathology. Mutation in the gene is associated with risk of rolandic epilepsy. Studies have shown that in presence of neurological disorders, the protein is mislocalized.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Electroacupuncture promotes neural stem cell proliferation and neurogenesis in the dentate gyrus of rats following stroke via upregulation of Notch1 expression.
Zhao J, et al.
Molecular Medicine Reports, 12(5), 6911-6917 (2015)
RBFOX1 and RBFOX3 mutations in rolandic epilepsy.
Lal D, et al.
PLoS ONE, 8(9), e73323-e73323 (2013)
RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts.
Li Y I, et al.
Genome Research, 25(1), 1-13 (2015)
NeuN as a neuronal nuclear antigen and neuron differentiation marker.
Gusel'Nikova V V and D E Korzhevskiy
Acta Naturae, 7(2 (25)) (2015)
Dong-Xue Zhang et al.
Neurochemistry international, 139, 104784-104784 (2020-07-12)
Hemorrhagic shock and resuscitation (HSR) may lead to long-term neurological dysfunction, such as depression and anxiety. Carbon monoxide (CO) has emerged as an excellent neuroprotective agent against caspase-1-associated pyroptosis, following HSR. We evaluated the effects and determined the mechanism through
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