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Key Documents

SAB3500310

Sigma-Aldrich

Anti-IL-23 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-IL-27 p28, Anti-Interleukin-27

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 21 kDa

species reactivity

human, mouse

technique(s)

immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

AAH66268

UniProt accession no.

Q9NPF7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL23A(51561)

General description

IL-23 is a pro-inflammatory cytokine. It is mostly synthesized by activated DC (dendritic cells) and macrophages. It is a 20.7 kDa protein that has 189 amino acids. IL-23 is mostly expressed on activated/memory T cells and natural killer (NK) cells. This gene is located on human chromosome 12q13.3.

Immunogen

IL-23 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human IL-23.

Application

Anti-IL-23 antibody has been used in western blotting.

Biochem/physiol Actions

The IL-23 plays a major role in cutaneous immune-mediated inflammatory diseases like psoriasis, allergic contact dermatitis and atopic dermatitis. It is involved in cellular immunity driving the expansion, stabilization and survival of Th17 cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500310.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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IL23A (interleukin 23, alpha subunit p19)
Inoue N
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2011)
L Zhang et al.
Scandinavian journal of immunology, 87(1), 36-45 (2017-11-10)
This study (1) analysed the percentage of γδ T cells, γδ T cell subsets, Th17 cells and regulatory T cells (Treg cells) and (2) determined the role of IL-23 in primary nephrotic syndrome (PNS) patients with active disease and in
Osmotin Protects H9c2 Cells from Simulated Ischemia-Reperfusion Injury through AdipoR1/PI3K/AKT Signaling Pathway
Liu J, et al.
Frontiers in Physiology (2017)
Expression of IL-23/Th17-related cytokines in basal cell carcinoma and in the response to medical treatments
Pellegrini C, et al.
PLoS ONE (2017)
Jianhua Liu et al.
Frontiers in physiology, 8, 611-611 (2017-10-11)
Objective: This study aimed to investigate the effect of osmotin on myocardial ischemia/reperfusion (I/R), as well as the underlying mechanisms. Methods:In vitro I/R injury model was established on rat cardiac myoblast H9c2 cells by oxygen and glucose deprivation followed by
View All Related Papers

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