SAB3500202

Anti-SIRPα antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(s): Anti-SHPS-1, Anti-SIRPa
• MDL number: MFCD01634182
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: rat, mouse, human
• technique(s): immunocytochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI accession no.: NP_542970
• UniProt accession no.: P78324
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... SIRPA(140885)

Description

General description

Signal regulatory protein α (SIRPα) is expressed in dendritic cells and macrophages. It is a cell-surface protein. The protein possesses a highly glycosylated extracellular region, three immunoglobin superfamily domains and an intracellular domain with immunoreceptor tyrosine-based inhibitory motifs. The gene encoding SIRPα is localized on human chromosome 20p13.

Immunogen

SIRP alpha antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human SIRP alpha 1? The sequences of the immunogenic peptide differ from those of mouse, rat and bovine by one amino acid.

Biochem/physiol Actions

Signal regulatory protein α (SIRPα) acts as a modulator of immune responses. It has a role in the migration, adhesion, growth and differentiation of cells. SIRPα associates with cluster of differentiation 47 (CD47) and prevents phagocytosis by macrophages.

Features and Benefits

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Linkage

The action of this antibody can be blocked using blocking peptide SBP3500202.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable