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Key Documents

SAB1408054

Sigma-Aldrich

Anti-RNF146 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(s):

DKFZp434O1427, RP3-351K20.1, dJ351K20.1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~38.8 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

NM_030963.2

UniProt accession no.

Q9NTX7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RNF146(81847)

Immunogen

RNF146 (NP_112225.2, 1 a.a. ~ 358 a.a) full-length human protein.

Sequence
MAGCGEIDHSINMLPTNRKANESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDANTVNLARESSADGADSVSAQSGASVQPLVSSVRPLTSVDGQLTSPATPSPDASTSLEDSFAHLQLSGDNTAERSHRGEGEEDHESPSSGRVPAPDTSIEETESDASSDSEDVSAVVAQHSLTQQRLLVSNANQTVPDRSDRSGTDRSVAGGGTVSVSVRSRRPDGQCTVTEV

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
DaRosa PA
Nature, 517, 223-223 (2015)
RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.
Matsumoto Y, et. al.
The Journal of Clinical Investigation, 127, 1303-1303 (2017)
Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism.
Matsumoto Y, et. al.
The Journal of Clinical Investigation, 127, 2612-2612 (2017)
Overexpression of RNF146 in non-small cell lung cancer enhances proliferation and invasion of tumors through the Wnt/?-catenin signaling pathway.
Gao Y
PLoS ONE, 9, e85377-e85377 (2014)
Yoshinori Matsumoto et al.
The Journal of clinical investigation, 127(7), 2612-2625 (2017-06-06)
Cleidocranial dysplasia (CCD) is an autosomal dominant human disorder characterized by abnormal bone development that is mainly due to defective intramembranous bone formation by osteoblasts. Here, we describe a mouse strain lacking the E3 ubiquitin ligase RNF146 that shows phenotypic
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