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P0022

Sigma-Aldrich

PS48

≥98% (HPLC)

Synonym(s):

5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid

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About This Item

Empirical Formula (Hill Notation):
C17H15ClO2
CAS Number:
1180676-32-7
Molecular Weight:
286.75
MDL number:
MFCD17215962
UNSPSC Code:
12352200
PubChem Substance ID:
329819977
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to off-white

solubility

DMSO: >20 mg/mL

storage temp.

2-8°C

SMILES string

OC(=O)\C=C(\CCc1ccc(Cl)cc1)c2ccccc2

InChI

1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12-

InChI key

LLJYFDRQFPQGNY-QINSGFPZSA-N

Biochem/physiol Actions

PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Satoshi Watanabe et al.
Biology of reproduction, 100(2), 523-534 (2018-08-31)
Spermatogonial stem cells (SSCs) provide the foundation of spermatogenesis. However, because of their small number and slow self-renewal, transfection of SSCs has met with limited success. Although several viral vectors can infect SSCs, genome integration and an inability to maintain
Mito Kanatsu-Shinohara et al.
The Journal of reproduction and development, 64(6), 511-522 (2018-09-04)
Stem cell homing is a complex phenomenon that involves multiple steps; thus far, attempts to increase homing efficiency have met with limited success. Spermatogonial stem cells (SSCs) migrate to the niche after microinjection into seminiferous tubules, but the homing efficiency
Shun Watanabe et al.
Pflugers Archiv : European journal of physiology, 468(4), 667-677 (2015-11-19)
Hyperinsulinemia associated with type 2 diabetes may contribute to the development of vascular diseases. Although we recently reported that enhanced contractile responses to serotonin (5-hydroxytryptamine, 5-HT) are observed in the arteries of type 2 diabetes models, the causative factors and
Bethany R Mordhorst et al.
Molecular reproduction and development, 85(4), 290-302 (2018-02-03)
Somatic cell nuclear transfer is a valuable technique for the generation of genetically engineered animals, however, the efficiency of cloning in mammalian species is low (1-3%). Differentiated somatic cells commonly used in nuclear transfer utilize the tricarboxylic acid cycle and
Steven B Daines et al.
The Journal of arthroplasty, 32(1), 274-279 (2016-08-16)
Increased range of motion to higher degrees of flexion following total knee arthroplasty has been postulated to increase implant damage and revision rates, even in designs modified to accommodate high flexion. We examined posterior-stabilized and high-flexion retrieved tibial inserts to
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