O2375

L-Ornithine monohydrochloride

≥99%

• Synonym(s): (S)-2,5-Diaminopentanoic acid monohydrochloride
• Empirical Formula (Hill Notation): C₅H₁₂N₂O₂ · HCl
• CAS Number: 3184-13-2
• Molecular Weight: 168.62
• Beilstein: 3625847
• EC Number: 221-678-6
• MDL number: MFCD00064562
• UNSPSC Code: 12352209
• PubChem Substance ID: 24897960
• NACRES: NA.26

Properties

• Quality Level: 200
• Assay: ≥99%
• form: powder
• impurities: ammonia and citrulline, essentially free
• color: white
• application(s): cell analysis
• SMILES string: Cl.NCCC[C@H](N)C(O)=O
• InChI: 1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m0./s1
• InChI key: GGTYBZJRPHEQDG-WCCKRBBISA-N

Description

Application

L-Ornithine monohydrochloride has been used to study the blocking effect of L-ornithine on the transport system that carries L-arginine for the overproduction of nitric oxide during lipopolysaccharide induced endotoxemia in rat model. It has also been used in decarboxylation test of amino acids.

Biochem/physiol Actions

L-Ornithine is a product of arginase degradation and plays an important role in ammonia metabolism via the urea cycle. In mammals, ornithine serves as a precursor for polyamines and proline biosynthesis. Spermine synthesized from ornithine, is an abundant polyamine observed in tumors such as breast carcinomas. Administration of L-ornithine is known to improve subjective index of sleep quality. L-ornithine reduces the cortisol/DHEA-S (dehydroepiandrosterone) ratio, that is associated with stress. In mice, L-ornithine is found to affect the levels of plasma growth hormone, corticosterone and melatonin levels in mice.

Other Notes

Product of arginine degradation by arginase

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves