I5784
Ibandronate sodium salt
≥97% (NMR), solid
Synonym(s):
(1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid sodium, Bondronat
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About This Item
Empirical Formula (Hill Notation):
C9H22NNaO7P2
CAS Number:
Molecular Weight:
341.21
MDL number:
UNSPSC Code:
41106300
PubChem Substance ID:
NACRES:
NA.77
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Quality Level
Assay
≥97% (NMR)
form
solid
storage condition
protect from light
color
white
solubility
H2O: >10 mg/mL
originator
Roche
storage temp.
2-8°C
SMILES string
[Na+].CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)([O-])=O
InChI
1S/C9H23NO7P2.Na/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17;/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17);/q;+1/p-1
InChI key
LXLBEOAZMZAZND-UHFFFAOYSA-M
Gene Information
human ... FDPS(2224)
Application
Ibandronate sodium salt has been used to study its effect on the proliferation and ultrastructure of Leishmania and Giardia by the generation of concentration curves. It has also been used to elucidate the route by which nitrogen-containing bisphosphonates (N-BPs) enter the cytosol and inhibit their molecular target.
Biochem/physiol Actions
Ibandronate is a nitrogen-containing bisphosphonate (N-BP). It potentially inhibits mevalonate pathway in osteoclasts. Thus, ibandronate is effectively used to treat osteoporosis and other bone-related diseases.
Ibandronate sodium inhibits farnesyl diphosphate synthase (IC50 = 20 nM). Ibandronate sodium is also a bone resorption inhibitor. It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.
Features and Benefits
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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