H7125

Histamine

≥97% (TLC), powder, H₁ and H₂ histamine receptor agonist

• Synonym(s): 2-(4-Imidazolyl)ethylamine
• Empirical Formula (Hill Notation): C₅H₉N₃
• CAS Number: 51-45-6
• Molecular Weight: 111.15
• Beilstein: 2012
• EC Number: 200-100-6
• MDL number: MFCD00005210
• UNSPSC Code: 12352116
• eCl@ss: 32160406
• PubChem Substance ID: 24895783
• NACRES: NA.77

Properties

• Product Name: Histamine, ≥97.0%
• Quality Level: 200
• Assay: ≥97.0%
• bp: 167 °C/0.8 mmHg (lit.)
• mp: 83-84 °C (lit.)
• storage temp.: −20°C
• SMILES string: NCCc1c[nH]cn1
• InChI: 1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
• InChI key: NTYJJOPFIAHURM-UHFFFAOYSA-N
• Gene Information: human ... CA1(759) , CA2(760) , HRH1(3269) , HRH2(3274) , HRH3(11255) , HRH4(59340) ; rat ... Hrh1(24448) , Hrh3(85268)

Description

General description

Histamine is a neurotransmitter produced by neurons of the posterior hypothalamus. In the brain, histamine is predominantly present in the gray matter.

Application

Histamine has been used:

• to stimulate regulated cellular secretion
• in reaction mixture to activate blood for assaying thrombin (factor iia) activity by fluorimetry
• to fill the luminal side of the chamber to investigate its effects on the TJ-related barrier and the expression of TJ (tight junction) markers in the vocal fold epithelium

Biochem/physiol Actions

Endogenous H₁ and H₂ histamine receptor agonist; H₁ activation mobilizes Ca²⁺; H₂ activation stimulates adenylate cyclase activity in neurons; activates nitric oxide synthetase; potent vasodilator.

Histamine participates in innate and acquired immune response, mediating allergy and inflammation. It helps in intestinal muscle contraction. During anaphylactic shock histamine causes bronchial constriction. Histamine is also involved in gastric acid secretion, epithelial and endothelial barrier control.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301,H315,H317,H319,H334,H335
• Precautionary Statements: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves