F6771

Fumagillin from Aspergillus fumigatus

≥90%, powder

• Synonym(s): Fugillin
• Empirical Formula (Hill Notation): C₂₆H₃₄O₇
• CAS Number: 23110-15-8
• Molecular Weight: 458.54
• EC Number: 245-433-8
• MDL number: MFCD03990453
• UNSPSC Code: 12352200
• PubChem Substance ID: 24894920

Properties

• biological source: Aspergillus sp. (Aspergillus fumigatus)
• Quality Level: 200
• Assay: ≥90%
• form: powder
• color: white
• mp: 197-198 °C
• solubility: ethanol: 1 mg/mL
• antibiotic activity spectrum: fungi
• Mode of action: DNA synthesis | interferes
• storage temp.: −20°C
• SMILES string: COC1C(CCC2(CO2)C1C3(C)OC3C\C=C(\C)C)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O
• InChI: 1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+
• InChI key: NGGMYCMLYOUNGM-HCNIIHBUSA-N

Description

General description

Fumagillin is a metabolic product of fungi. It is originally isolated from Aspergillus fumigatus.

Application

Fumagillin from Aspergillus fumigatus has been used:

• in chick chorioallantoic membrane (CAM) assay to study the changes in protein expression in response to anti-angiogenic agent
• to study its effects on the mortality of caged Nosema ceranae-infected honey bees- write in this way
• as a positive control in in vitro and ex vivo studies

Biochem/physiol Actions

Fumagillin is known to be effective against microsporidian fungal infections.

Methionine aminopeptidase-2 (MetAP-2) inhibitor; inhibits endothelial cell proliferation and angiogenesis.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves