F4503
Ferritin from equine spleen
Type I, saline solution
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About This Item
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sterility
sterile-filtered
Quality Level
type
Type I
form
saline solution
mol wt
H subunit ~21 kDa
L subunit ~19 kDa
color
red to brown
cation traces
Cd: ≤1% (as % of ferritin)
storage temp.
2-8°C
General description
A shell of 24 protein subunits (apoferritin) and a core Fe 3+ ions with a peptide MW of 440 kDa. Review of the ferritin-like superfamily of iron-storage proteins, virtually ubiquitous in life on earth.
Application
Ferritin from equine spleen has been used:
- in mycobacterial growth assay
- in size-exclusion chromatography
- in labeling of macrophage cells
- as a reference standard in muon spin spectroscopy
Biochem/physiol Actions
A ubiquitous iron storage protein that plays a key role in iron metabolism. It serves as an intracellular iron reserve (particularly in spleen, liver, intestinal mucosa, and bone marrow) and functions in iron detoxification. Studies have shown that ferritin iron incorporation is mediated by a ferroxidase activity associated with ferritin H subunits and a nucleation center associated with ferritin L subunits. Release of iron from ferritin has an essential role in iron-dependent lipid peroxidation and may contribute to free radical-induced cell damage in vivo. Therefore, by binding iron, ferritin may function as an antioxidant.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Shi Qiu et al.
Ultramicroscopy, 216, 113036-113036 (2020-06-17)
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Adipocyte model of Mycobacterium tuberculosis infection reveals differential iron availability to bacilli in the lipid rich caseous environment
Nandy A, et al.
Infection and Immunity, IAI-00041 (2018)
Sella Kim et al.
Journal of molecular biology, 428(24 Pt B), 5007-5018 (2016-11-03)
Iron and oxygen chemistry is mediated by iron proteins for many biological functions. Carboxylate-bridged diiron enzymes including ferritin have the common mechanism of oxygen activation via peroxodiferric intermediates. However, the route for iron uptake and the structural identification of intermediates
Defining the Architecture of the Core Machinery for the Assembly of Fe-S Clusters in Human Mitochondria
Methods in Enzymology, 595, 107-160 (2017)
Lucia Bossoni et al.
Magnetic resonance in medicine, 87(3), 1276-1288 (2021-10-17)
To employ an off-resonance saturation method to measure the mineral-iron pool in the postmortem brain, which is an endogenous contrast agent that can give information on cellular iron status. An off-resonance saturation acquisition protocol was implemented on a 7 Tesla
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