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EDFS

Sigma-Aldrich

Ethylenediaminetetraacetic acid iron(III) sodium salt

powder

Synonym(s):

EDTA iron(III) sodium salt, Edathamil, Komplexon™ II

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About This Item

Linear Formula:
C10H12N2NaFeO8
CAS Number:
15708-41-5
Molecular Weight:
367.05
EC Number:
239-802-2
MDL number:
MFCD00078215
UNSPSC Code:
12352202
PubChem Substance ID:
24894712
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

200

Agency

suitable for SM 5210

form

powder

composition

Iron, 13.7-18.7% ICP
Sodium, 5.6-7.9% ICP

reaction suitability

reagent type: chelator

concentration

≥67.5% (EDTA titration)

pH

4.5

mp

80 °C

solubility

water: 50 mg/mL, clear to slightly hazy, yellow to brown

storage temp.

room temp

SMILES string

[Na+].[Fe+3].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.Fe.Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;/q;+3;+1/p-4

InChI key

MKWYFZFMAMBPQK-UHFFFAOYSA-J

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Application

Used to eliminate enzyme inhibition by traces of heavy metals, and to inhibit enzymes that require divalent cations as cofactors. Iron-EDTA enhances damage due to reactive oxygen species, such as depletion of reduced glutathione, formation of methemoglobin, and lipid peroxidation.

Legal Information

Komplexon is a trademark of CU Chemie Uetikon AG

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Natasha T Forester et al.
Molecular plant-microbe interactions : MPMI, 32(10), 1324-1335 (2019-05-21)
In ascomycetes and basidiomycetes, iron-responsive GATA-type transcriptional repressors are involved in regulating iron homeostasis, notably to prevent iron toxicity through control of iron uptake. To date, it has been unknown whether this iron regulator contributes toward mutualistic endosymbiosis of microbes
Suying Chang et al.
Food and nutrition bulletin, 33(2), 111-116 (2012-08-23)
Ferric sodium ethylenediaminetetraacetate (NaFeEDTA) enhances iron absorption in the presence of phytate. However, the amount of NaFeEDTA that would have to be added to a complementary food to provide the necessary intake of iron for an infant or young child
Abdul-Razak Abizari et al.
The Journal of nutrition, 142(10), 1836-1842 (2012-08-24)
Cowpeas, like other legumes, contain high amounts of native iron but are rich in phytic acid (PA) and polyphenols (PP) that inhibit iron absorption. NaFeEDTA may overcome the combined inhibitory effect of PA and PP. Our objective was to test
Kwan-Young Jung et al.
Biochemistry, 50(28), 6273-6279 (2011-06-24)
Oxidation of the C5'-position of DNA results in direct strand scission. The 3'-fragments produced contain DNA lesions at their 5'-termini. The major DNA lesion contains an aldehyde at its C5'-position, but its nucleobase is unmodified. Excision of the lesion formed
Klaus Schümann et al.
Food and nutrition bulletin, 33(2), 128-136 (2012-08-23)
Oral iron supplementation with ferrous sulfate (FeSO₄) at dosage levels suggested by the international guidelines poses a safety hazard to young children with malaria. Exposure to loosely bound iron in the circulation has been advanced as a potential factor. To
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