E1407

Monoclonal Anti-Erythropoietin antibody produced in rat

clone 148438, purified immunoglobulin, lyophilized powder

• Synonym(s): Anti-EP, Anti-EPO, Anti-Epo
• MDL number: MFCD02096326
• UNSPSC Code: 51111800
• NACRES: NA.41

Properties

• biological source: rat
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 148438, monoclonal
• form: lyophilized powder
• species reactivity: mouse
• technique(s): neutralization: suitable
• isotype: IgG2a
• UniProt accession no.: P07321
• storage temp.: −20°C
• Gene Information: mouse ... Epo(13856)

Description

General description

Erythropoietin (Epo) is a pleotropic cytokine that promotes erythropoiesis or proliferation and differentiation of red blood cell precursors. Epo is mainly produced by liver cells in fetal stages, by kidneys under hypoxic conditions; liver and brain also secrete Epo is less amounts. The red blood cell production is stimulated when Epo binds and activates the Epo receptor (EpoR) dimer. EpoR directly regulates the signalling by Jak2, PI3K, NF-κB, STAT5A and STAT5B. Epo also inhibits apoptosis of erythroid progenitors by downregulating Fas and FasL. The expression of Epo is under the control of the transcription factor hypoxia inducible factor (HIF). Erythropoietin exhibits disease-modifying effects in infectious diseases and chronic inflammatory disorders
Monoclonal Anti-Erythropoietin antibody specifically reacts with mouse Erythropoietin.

Immunogen

purified, CHO cell-derived recombinant mouse erythropoietin.

Application

Monoclonal Anti-Erythropoietin antibody is suitable for neutralization reactions.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves