PHR1441

Spectinomycin Sulfate

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Spectinomycin sulfate tetrahydrate
• Empirical Formula (Hill Notation): C₁₄H₂₆N₂O₁₁S · 4H₂O
• CAS Number: 64058-48-6
• Molecular Weight: 502.49
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to Ph. Eur. Y0000655; traceable to USP 1618003
• API family: spectinomycin
• CofA: current certificate can be downloaded
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• InChI: 1S/C14H24N2O7.H2O4S.4H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;1-5(2,3)4;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;(H2,1,2,3,4);4*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;/m1...../s1
• InChI key: OBZDRKHRQYPQDZ-SACNDDTHSA-N

Description

General description

Spectinomycin is an aminoglycoside-like antibiotic produced by Streptomyces spectabilis. It is widely used as a veterinary medication to treat gastrointestinal and respiratory infections caused by a variety of spectinomycin-sensitive micro-organisms.

Application

Spectinomycin Sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in spectinomycin formulations using high-performance liquid chromatography technique.

Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Caution

Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.

Preparation Note

Stock solutions should be prepared at 10 mg/mL in water and filter sterilized.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3670 in the slot below. This is an example certificate only and may not be the lot that you receive.

Legal Information

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. This product was designed, produced and verified for accuracy and stability in accordance with ISO/IEC 17025:2005 (AClass Cert AT-1467), ISO GUIDE 34:2009 (AClass Cert AR-1470).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable