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H0800000

Homatropine hydrobromide

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

DL-Homatropine hydrobromide, DL-endo-α-Hydroxybenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrobromide, Tropine mandelate hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C16H21NO3 · HBr
CAS Number:
51-56-9
Molecular Weight:
356.25
MDL number:
MFCD00012676
UNSPSC Code:
41116107
PubChem Substance ID:
329815135
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

homatropine

manufacturer/tradename

EDQM

mp

214-217 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Br.CN1C2CCC1CC(C2)OC(=O)C(O)c3ccccc3

InChI

1S/C16H21NO3.BrH/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11;/h2-6,12-15,18H,7-10H2,1H3;1H

InChI key

DWSGTFTVBLXELC-UHFFFAOYSA-N

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General description

Homatropine hydrobromide is an anticholinergic agent and is commonly used as a mydriatic and cycloplegic drug in ophthalmology.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Brian M Thome et al.
Journal of chromatography. A, 1138(1-2), 291-300 (2006-11-14)
Over the past decade the moving bed process has become a commonly used tool for the continuous separation of chiral compounds, and its recent application to electrophoretic separations allows the technique to be used as a model system for moving
Homatropine and psychosis in Weill-Marchesani syndrome.
Anjaiah Madugula et al.
Journal of the American Academy of Child and Adolescent Psychiatry, 45(7), 769-770 (2006-07-13)
Determination of homatropine hydrobromide in eye drops by second-order derivative spectroscopy.
Leung C P, et al.
Journal of Pharmaceutical and Biomedical Analysis, 9(2), 195-198 (1991)
Bhavna Chawla et al.
International ophthalmology, 29(1), 53-55 (2007-11-17)
To report a case of peripheral ulcerative keratitis (PUK) and scleritis, along with bilateral optic nerve infiltration as an initial presentation of acute lymphocytic leukemia (ALL) in an adult. Observational case report. A 24-year-old patient presented with complaints of pain
Robert Meek et al.
Emergency medicine Australasia : EMA, 22(6), 507-513 (2010-12-15)
To compare the change in visual analogue scale (VAS) pain ratings over 24 h following mechanical corneal abrasion between patients receiving sixth hourly drops of either 5% homatropine or placebo. A triple blind randomized controlled trial was conducted on a
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