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Key Documents

MAB3310

Sigma-Aldrich

Anti-TIMP-2 Antibody, clone 67-4H11

clone 67-4H11, Chemicon®, from mouse

Synonym(s):

Tissue Inhibitor of Metalloproteinase-2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

67-4H11, monoclonal

species reactivity

rabbit, goat, guinea pig, rat, human, bovine, mouse

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_003255.4

UniProt accession no.

P16035

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... TIMP2(7077)

Specificity

The antibody specifically reacts with human TIMP-2.

SPECIES REACTIVITY:

Cross-reacts with mouse, rat, guinea pig, rabbit and bovine TIMP-2.

Immunogen

Synthetic peptide corresponding to amino acids 178-193 of human TIMP-2 (numbered from the propeptide)

YRGAAPPKQEFLDIED

Application

Anti-TIMP-2 Antibody, clone 67-4H11 detects level of TIMP-2 & has been published & validated for use in ELISA, WB, IH(P).
Immunoblotting

Immunohistochemistry on paraffin-embedded, PLP fixed tissue at 5 μg/mL (see Tomita reference) or frozen tissues at 1 μg/mL (see Ohashi reference).

ElA
Research Category
Cell Structure
Research Sub Category
MMPs & TIMPs

Linkage

Replaces: MAB3356

Physical form

Format: Purified
Liquid in 0.1M Na-Phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin.

Storage and Stability

Maintain frozen at -20°C in undiluted aliquots for up to 12 months.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Manufactured by Daiichi Fine Chemical Co., Ltd

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Fracture resistance and histological findings of immature teeth treated with mineral trioxide aggregate.
Sahza Hatibovic-Kofman, Lin Raimundo, Lei Zheng, Lawrence Chong, Manfred Friedman et al.
Dental Traumatology null
Expression of matrix metalloproteinase (MMP)-2, MMP-14 and tissue inhibitor of matrix metalloproteinase (TIMP)-2 during bovine placentation and at term with or without placental retention.
M Dilly,N Hambruch,S Shenavai,G Schuler,R Froehlich,J-D Haeger,G R Ozalp,C Pfarrer
Theriogenology null
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in colonic adenomas-adenocarcinomas.
Tomita, T and Iwata, K
Diseases of the Colon and Rectum, 39, 1255-1264 (1996)
ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease.
Kuefer, R; Day, KC; Kleer, CG; Sabel, MS; Hofer, MD; Varambally, S; Zorn, CS; Chinnaiyan et al.
Neoplasia null
TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP.
Han, YP; Tuan, TL; Wu, H; Hughes, M; Garner, WL
Journal of Cell Science null
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