377980

Hispidin

A potent, cell permeable, and reversible inhibitor of protein kinase Cβ isoform (PKCβ; IC₅₀ = 2 µM).

• Synonym(s): Hispidin, 6-(3,4-Dihydroxystyrl)-4-hydroxy-2-pyrone
• Empirical Formula (Hill Notation): C₁₃H₁₀O₅
• CAS Number: 555-55-5
• Molecular Weight: 246.22
• MDL number: MFCD01866972
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥90% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,15-17H/b3-1+

Description

General description

A potent, cell permeable, and reversible inhibitor of protein kinase C_β isoform (PKC_β; IC₅₀ = 2 µM). Has stronger cytotoxic effects on cancer cells than on normal cells in vitro.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKCβ

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 2 µM against PKCβ

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Gonindard, C., et al. 1997. Cell Biol. Toxicol. 13, 141.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): No data available
• Flash Point(C): No data available