1.06762

Ninhydrin

GR for analysis ACS,Reag. Ph Eur

• Synonym(s): Ninhydrin, 2,2-Dihydroxy-1,3-dioxohydrindene, 2,2-Dihydroxy-1,3-indandione, Indantrione hydrate, Triketohydrindene hydrate
• Empirical Formula (Hill Notation): C₉H₆O₄
• CAS Number: 485-47-2
• Molecular Weight: 178.14
• MDL number: MFCD00003791
• UNSPSC Code: 12352115
• EC Index Number: 207-618-1
• NACRES: NA.21

Properties

• grade: ACS reagent
• Quality Level: 100
• Agency: reag. Ph. Eur.
• form: solid
• potency: 600 mg/kg LD₅₀, oral (Rat)
• pH: 4.6-5.0 (20 °C, 10 g/L in H₂O)
• mp: 250-258 °C (decomposition)
• bulk density: 680 kg/m³
• storage temp.: 15-25°C
• InChI: 1S/C9H6O4/c10-7-5-3-1-2-4-6(5)8(11)9(7,12)13/h1-4,12-13H
• InChI key: FEMOMIGRRWSMCU-UHFFFAOYSA-N

Description

Application

• Development of aminolyzed polylactic acid-based porous films for pH-responsive sustained drug delivery devices: This research highlights the use of Ninhydrin in developing advanced drug delivery systems, particularly in pH-responsive applications for controlled release, emphasizing its role in pharmaceutical innovations (Rafique et al., 2024).


• Crystal structure and solution scattering of Geobacillus stearothermophilus S9 peptidase reveal structural adaptations for carboxypeptidase activity: Ninhydrin is utilized in this study to understand the enzymatic mechanisms and structural adaptations of proteins, contributing significantly to biochemical research and enzyme therapy (Chandravanshi et al., 2024).


• TiO(2)/Ag-based photodeposited catalyst boosted electrochemiluminescence of ninhydrin-hydrogen peroxide system for ultrasensitive sensing of copper (II): Demonstrates the application of Ninhydrin in environmental monitoring, particularly in the detection of metal ions, showcasing its potential in environmental science and analytical chemistry (Xiong et al., 2024).


• Synthesis of aminolyzed gelatin-mediated chitosan as pH-responsive drug-carrying porous scaffolds: Highlights the use of Ninhydrin in biomedical engineering, specifically in the creation of biocompatible scaffolds for tissue engineering and regenerative medicine (Sarwar et al., 2024).


• Periodic and non-periodic DFT studies of an organic semiconductor material: Structural, electronic, optical, and vibrational properties of ninhydrin: This study explores the fundamental properties of Ninhydrin as an organic semiconductor, contributing to the understanding of its electronic and structural characteristics which are crucial for the development of new semiconductor materials (Benaissa et al., 2024).

Analysis Note

Identity (IR-spectrum): conforms
Appearance: White to yellow or brownish white crystalline powder or crystals.
Solubility (10 g/l, water): conforms
Melting point: about 250
Suitability for amino acid analysis: conforms

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H315,H319
• Precautionary Statements: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable