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Z-004

Supelco

Zaleplon solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C17H15N5O
CAS Number:
151319-34-5
Molecular Weight:
305.33
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

CCN(C(C)=O)c1cccc(c1)-c2ccnc3c(cnn23)C#N

InChI

1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3

InChI key

HUNXMJYCHXQEGX-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRB1(2560) , GABRG2(2566)

Related Categories

General description

Zaleplon is a nonbenzodiazepine “Z-drug” prescribed under the trade names Sonata® or Starnoc for the treatment of insomnia. Zaleplon is often abused illicitly for its mind-altering effects. This Certified Spiking Solution® is applicable to use in LC/MS or GC/MS applications for urine drug testing, clinical toxicology, and forensic analysis.

Application


  • Controlled pore glass beads: Controlled pore glass can be employed for sustainable functionalized metal-organic frameworks for CO2 separation, showcasing the material′s effectiveness in environmental applications due to its high BET surface area which enhances gas adsorption properties (Babar et al., 2021).

  • Porous glass for protein adsorption: Mesoporous nano-bioglass for controlled drug release, highlights the application of controlled pore glass with high surface areas in pharmaceutical formulations to enhance the delivery and efficacy of therapeutic agents (Shoaib et al., 2017).

  • Surface characterization materials: It can be employed for the contact angle hysteresis of materials with controlled pore structures, to understand the wetting properties of high surface area materials like controlled pore glass, which is critical in various industrial and biomedical applications (Salmas and Androutsopoulos, 2001).


Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Sonata is a registered trademark of King Pharmaceuticals Research and Development, Inc.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Adam R Lancaster et al.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 21(6), 658-665 (2012-02-10)
To summarize the signalment, clinical signs observed, time to onset of clinical signs, duration of clinical signs, and the outcome in a large case series of nonbenzodiazepine sleep aid ingestions in dogs, including 2 sleep aids that have not been
Karthik Y Janga et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 80(2), 347-357 (2011-11-02)
The present systematic study focused to investigate the combined advantage of proliposomes and surface charge for improved oral delivery of zaleplon. The zaleplon loaded proliposomes were prepared using hydrogenated soyphosphatidylcholine (HSPC) and cholesterol (CHOL) in varying ratios, and the optimized
David J Greenblatt et al.
Biopharmaceutics & drug disposition, 32(9), 489-497 (2011-09-22)
Two investigations aimed to define the pharmacokinetic profile of a modified-release preparation of zaleplon (SKP-1041). Protocol SOM001 was a 5-way crossover, double-blind, randomized trial comparing three novel modified-release formulations of zaleplon 15 mg (SKP-1041A, SKP-1041B, SKP-1041C) to placebo and immediate-release
Kirsten Wiese Simonsen et al.
Journal of analytical toxicology, 34(6), 332-341 (2010-07-29)
An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method for detection of 23 benzodiazepines and related compounds in whole blood was developed and validated. The method is used for screening and quantitation of benzodiazepines in whole blood received from autopsy cases
Michael J Avram et al.
Journal of clinical pharmacology, 53(2), 140-150 (2013-02-26)
Pharmacokinetics, pharmacodynamics, safety, and tolerability of inhaled zaleplon were assessed in healthy volunteers. Forty participants received 0.5, 1, 2, or 4 mg zaleplon or placebo as a thermally generated aerosol in a randomized, double-blind, parallel-group, dose escalation study. Blood was
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Articles

HPLC Analysis of Z-Drugs on Ascentis® Express ES-Cyano 2.0 μm

An rapid method for the siµLtaneous determination of the Z-drugs or sleep aids: zopiclone, zolpidem, and zaleplon is presented here. The need for greater analytical capacity and throughput for the analysis of sleep aid medicines (Z-drugs) in forensic toxicology laboratories can be met by the use of fast Ascentis Express 2.0 micron Fused Core UHPLC Columns.

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