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860637P

Avanti

Galactosyl(β) Sphingosine-d5

Avanti Research™ - A Croda Brand 860637P, powder

Synonym(s):

D-galactosyl-β1-1′-D-erythro-sphingosine-d5

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About This Item

Empirical Formula (Hill Notation):
C24H42D5NO7
CAS Number:
2260670-12-8
Molecular Weight:
466.66
UNSPSC Code:
12352211
NACRES:
NA.12

form

powder

packaging

pkg of 1 × 1 mg (860637P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860637P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCC([2H])(C([2H])([2H])[2H])[2H])(O)[C@](N)([H])CO[C@H](O1)[C@H](O)[C@@H](O)[C@H]([C@H]1CO)O

Application

Galactosyl(β) Sphingosine-d5 has been used as an internal standard for the quantification of galactosylsphingosine, in the extracts from the mouse cerebellum by liquid chromatography-tandem mass spectrometry.

Biochem/physiol Actions

Galactosylsphingosine, also known as psychosine, has an ability to induce apoptosis in various types of cells including oligodendrocytes. It is a toxic metabolite. Accumulation of this cytotoxic sphingolipid in the brain due to the deficiency of galactocerebrosidase (GALC) leads to the development of Krabbe disease.

Packaging

5 mL Amber Glass Screw Cap Vial (860637P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Victoria Schiffer et al.
PloS one, 15(1), e0227077-e0227077 (2020-01-14)
Gaucher disease is caused by a deficiency in glucocerebrosidase that can result in non-neuronal as well as neuronal symptoms. Common visceral symptoms are an increased organ size, specifically of the spleen, and glucosylceramide as well as glucosylsphingosine substrate accumulations as

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