810267P
Avanti
C11 TopFluor® Glucosyl Ceramide
Avanti Polar Lipids 810267P, powder
Synonym(s):
N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-glucosyl-β1-1′-D-erythro-sphingosine
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About This Item
Empirical Formula (Hill Notation):
C48H80N3O8F2
CAS Number:
Molecular Weight:
865.16
UNSPSC Code:
12352211
NACRES:
NA.25
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Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 250 μg (810267P-250ug)
manufacturer/tradename
Avanti Polar Lipids 810267P
shipped in
dry ice
storage temp.
−20°C
General description
Glucosyl Ceramide (GlcCer)/cerebroside/galactosylceramide is a neutral, polar lipid. It can be ionized delicately in negative-and positive-ion modes. It is the simplest glycosphingolipids (GSLs), that is present abundantly in the mammalian tissues. GlcCer is produced through glycosylation of Cer with the help of GlcCer synthase (GCS) at the cytosolic leaflet of Golgi apparatus.
Application
C11 TopFluor® Glucosyl Ceramide is suitable to use as a label in the GLM II model and as a component in the usual giant unilamellar vesicle (GUV) lipid mixture (GLM).
Biochem/physiol Actions
Glucosyl ceramide (GlcCer) plays a major role in the pathways of glycosphingolipid metabolism. It helps to modulate cell physiology. It acts as an intracellular messenger in cell maintenance and regulation.
Packaging
5 mL Amber Glass Screw Cap Vial (810267P-250ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
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Characterization of Lipids by Electrospray Ionization Mass Spectrometry, Lipid Analysis
Lipid analysis (2012)
Effect of glucosylceramide on the biophysical properties of fluid membranes
Varela ARP, et al.
Biochimica et Biophysica Acta - Biomembranes, 1828(3), 1122-1130 (2013)
Omid Motabar et al.
Analytical and bioanalytical chemistry, 402(2), 731-739 (2011-10-29)
Glucocerebrosidase is a lysosomal enzyme that catalyzes the hydrolysis of glucosylceramide to form ceramide and glucose. A deficiency of lysosomal glucocerebrosidase due to genetic mutations results in Gaucher disease, in which glucosylceramide accumulates in the lysosomes of certain cell types.
Lipid segregation and membrane budding induced by the peripheral membrane binding protein annexin A2
Drucker P, et al.
Test, 288(34), 24764-24776 (2013)
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