Skip to Content
Merck
All Photos(3)

Key Documents

More Documents

856525

Sigma-Aldrich

2-Methyl-1,2-di-3-pyridyl-1-propanone

96%

Synonym(s):

Metyrapone, Su-4885

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Empirical Formula (Hill Notation):
C14H14N2O
CAS Number:
54-36-4
Molecular Weight:
226.27
Beilstein:
163023
EC Number:
200-206-2
MDL number:
MFCD00006397
UNSPSC Code:
12352100
PubChem Substance ID:
24888424
NACRES:
NA.22

Quality Level

100

Assay

96%

form

powder

mp

52-55 °C (lit.)

SMILES string

CC(C)(c1cccnc1)C(=O)c2cccnc2

InChI

1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3

InChI key

FJLBFSROUSIWMA-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

2-Methyl-1,2-di-3-pyridyl-1-propanone inhibits the biosynthesis of corticosterone by blocking the conversion of deoxycorticosterone to corticosterone. It is widely used in adrenocortical-related clinical studies.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Secretion of cortisol and aldosterone as a vulnerable target for adrenal endocrine disruption?screening of 30 selected chemicals in the human H295R cell model.
Uller?s E, et al.
Journal of Applied Toxicology, 28(8), 1045-1053 (2008)
The relationship between adrenocortical function and Hsp70 expression in socially isolated Japanese quail.
Soleimani AF, et al.
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, 161(2), 140-144 (2012)
Laia Ribas et al.
The Journal of experimental biology, 220(Pt 6), 1056-1064 (2017-01-14)
The zebrafish (Danio rerio) has become a well-established experimental model in many research fields but the loss of the primary sex-determining region during the process of domestication renders laboratory strains of zebrafish susceptible to the effects of environmental factors on
Screening for modulatory effects on steroidogenesis using the human H295R adrenocortical cell line: a metabolomics approach.
Rijk JCW, et al.
Chemical Research in Toxicology, 25(8), 1720-1731 (2012)
Therese Koal et al.
The Journal of steroid biochemistry and molecular biology, 129(3-5), 129-138 (2012-01-03)
In order to overcome many limitations of immunoassays, high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) has the potential to find its place in the clinical laboratory medicine for quantification of steroid hormones. A prerequisite for the application of a new
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service