694746

Bis(3,5-di(trifluoromethyl)phenyl)chlorophosphine

• Synonym(s): P,P-Bis[3,5-bis(trifluoromethyl)phenyl]phosphinous chloride
• Empirical Formula (Hill Notation): C₁₆H₆ClF₁₂P
• CAS Number: 142421-57-6
• Molecular Weight: 492.63
• MDL number: MFCD01630852
• UNSPSC Code: 12352002
• PubChem Substance ID: 329761683
• NACRES: NA.22

Properties

• form: solid
• reaction suitability: reaction type: Buchwald-Hartwig Cross Coupling Reaction; reaction type: Heck Reaction; reaction type: Hiyama Coupling; reaction type: Negishi Coupling; reaction type: Sonogashira Coupling; reaction type: Stille Coupling; reaction type: Suzuki-Miyaura Coupling; reagent type: ligand
• mp: 25-29 °C
• functional group: phosphine
• SMILES string: FC(F)(F)c1cc(cc(c1)C(F)(F)F)P(Cl)c2cc(cc(c2)C(F)(F)F)C(F)(F)F
• InChI: 1S/C16H6ClF12P/c17-30(11-3-7(13(18,19)20)1-8(4-11)14(21,22)23)12-5-9(15(24,25)26)2-10(6-12)16(27,28)29/h1-6H
• InChI key: DFZQEHBNAJGDCT-UHFFFAOYSA-N

Description

Application

Reactant for synthesis of:

• Chiral phosphine-aminophosphine ligands for rhodium-catalyzed asymmetric hydrogenation
• Ligands for palladium-catalyzed stereoselective allylation reactions
• Ligands for enantioselective hydrogenations
• Josiphos analog as catalyst for asymmetric hydrogenation
• Ligands used in asymmetric hydrovinylation reactions

Reactant for enantioselective hydrogenation reactions catalyzed by Ru-(phosphine-oxazoline) complexes

Safety Information

• Pictograms: GHS02,GHS05
• Signal Word: Danger
• Hazard Statements: H261,H314
• Precautionary Statements: P231 + P232 - P280 - P305 + P351 + P338 - P310 - P422
• Hazard Classifications: Skin Corr. 1B - Water-react 3
• Storage Class Code: 4.3 - Hazardous materials which set free flammable gases upon contact with water
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves