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47889

Supelco

Methyl Paraben

PESTANAL®, analytical standard

Synonym(s):

Methyl 4-hydroxybenzoate, p-Hydroxybenzoic acid methyl ester, Methyl paraben, NIPAGIN

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About This Item

Linear Formula:
HOC6H4CO2CH3
CAS Number:
Molecular Weight:
152.15
Beilstein:
509801
EC Number:
MDL number:
UNSPSC Code:
12164500
PubChem Substance ID:
E Number:
E218

grade

analytical standard

Quality Level

product line

PESTANAL®

CofA

current certificate can be downloaded

packaging

ampule of 1000 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

125-128 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

storage temp.

2-30°C

SMILES string

COC(=O)c1ccc(O)cc1

InChI

1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3

InChI key

LXCFILQKKLGQFO-UHFFFAOYSA-N

Gene Information

rat ... Ar(24208)

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General description

Methyl Paraben is a stable, non-volatile, methyl ester of p-hydroxybenzoic acid. It can find applications as a broad-spectrum antimicrobial preservative in foods, drugs and cosmetics. It is found to be noncarcinogenic and is highly effective against fungi like molds and yeast as well as bacteria.
Methyl paraben is basically a methyl ester of p-hydroxybenzoic acid. It is non-toxic, and non-carcinogenic in nature. It is a stable, non-volatile compound and finds application as an anti-microbial preservative in foods, drugs and cosmetics. It is readily absorbed through the skin and gastrointestinal tract. Upon hydrolyzation, it is hydrolyzed to p-hydroxybenzoic acid, and the conjugates formed get rapidly excreted in the urine.

Application

Methyl paraben was used a preservative standard in commercial food products, during an experimental investigation, done to study the application of microemulsion electrokinetic chromatography (MEEKC), in detecting food preservatives.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Environment

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

334.4 °F

Flash Point(C)

168 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Combined activation of methyl paraben by light irradiation and esterase metabolism toward oxidative DNA damage
Okamoto Y, et al.
Chemical Research in Toxicology, 21, 1594-1599 (2008)
Application of microemulsion electrokinetic chromatography for the detection of preservatives in foods.
Huang H.y
Food Chemistry, 89 (2), 315-322 (2005)
Evaluation of the health aspects of methyl paraben: a review of the published literature
Soni.G.M, et al.
Food And Chemical Toxicology, 40, 1335-1373 (2002)
Chul-Hong Kim et al.
Genes, 12(2) (2021-03-07)
Bisphenol A (BPA) is a xenoestrogen chemical commonly used to manufacture polycarbonate plastics and epoxy resin and might affect various human organs. However, the cellular effects of BPA on the eyes have not been widely investigated. This study aimed to
Evaluation of the health aspects of methyl paraben: a review of the published literature.
Soni MG
Food And Chemical Toxicology, 40 (10), 1335-1373 (2002)

Protocols

Separation of Uracil; p-Aminobenzoic acid; Acetylsalicylic acid; Dehydroacetic acid; Benzoic acid; Methyl paraben; 3-Fluorobenzoic acid

Separation of Methyl Paraben, analytical standard; Ethylparaben, United States Pharmacopeia (USP) Reference Standard; Propylparaben, United States Pharmacopeia (USP) Reference Standard; Butylparaben, United States Pharmacopeia (USP) Reference Standard

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