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SRP4038

Sigma-Aldrich

Fgf-2 from mouse

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Synonym(s):

FGF-b, Fibroblast Growth Factor-basic, HBGF-2 Prostatropin

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About This Item

MDL number:
UNSPSC Code:
12352202
NACRES:
NA.32

Pricing and availability is not currently available.

biological source

mouse

recombinant

expressed in E. coli

Assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

mol wt

~16.3 kDa

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

NCBI accession no.

UniProt accession no.

General description

FGF-2 (fibroblast growth factor 2) is a basic heparin binding growth factor.[1] It is ubiquitously expressed and belongs to the FGF family.[2] It is also referred to as BFGF (basic fibroblast growth factor). The recombinant mouse FGF-2 is a single, non-glycosylated chain containing 145 amino acids and having a molecular weight of 16.3kDa.

Biochem/physiol Actions

FGF-2 (fibroblast growth factor 2, also referred to as BFGF (basic fibroblast growth factor)) stimulates the proliferation of a wide variety of cells including mesenchymal, neuroectodermal and endothelial cells.[3][4][5] It is present in the preimplantation embryos and is important for proper development.[6] It is also responsible for angiogenesis.[2] FGF-2 plays a crucial role in adipogenesis and development of adipose tissues.[7] It is associated with tumor growth and metastasis.[8]

Physical form

Sterile filtered and Lyophilized without additives.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in sterile water to 100 μg/mL.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Yongyi Wang et al.
PloS one, 7(7), e40691-e40691 (2012-08-01)
In fertile women, the endometrium undergoes regular cycles of tissue build-up and regression. It is likely that uterine stem cells are involved in this remarkable turn over. The main goal of our current investigations was to identify slow-cycling (quiescent) endometrial
Interleukin-1? induces fibroblast growth factor 2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes.
Chien SY
Clinical Science, 130, 667-681 (2016)
Blocking FGF2 with a new specific monoclonal antibody impairs angiogenesis and experimental metastatic melanoma, suggesting a potential role in adjuvant settings.
de Aguiar RB
Cancer Letters, 371, 151-160 (2016)
Biphasic effects of FGF2 on adipogenesis.
Kim S
PLoS ONE, 10, e0120073-e0120073 (2015)
Binding of FGF2 to FGFR2 in an autocrine mode in trophectoderm cells is indispensable for mouse blastocyst formation through PKC-p38 pathway.
Yang J
Cell Cycle, 14, 3318-3330 (2015)

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